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BEGIN:VEVENT
DTSTAMP:20260507T081915Z
DTSTART:20260507T130000Z
DTEND:20260507T140000Z
SUMMARY:HIMR Sponsored Seminar: Katie Bentley -- Temporal regulation of v
 ascular patterning: in silico\, in vitro and in vivo [IN PERSON]
UID:{http://www.columbasystems.com/customers/uom/gpp/eventid/}m1q7-mm3dnx
 tf-79i8mq
DESCRIPTION:Join us for this seminar by Katie Bentley (KCL/Crick) as part
  of the Maths in the Life Sciences seminar series (and the online North 
 West Seminar Series in Mathematical Biology and Data Sciences in collabo
 ration with Liverpool Universities). \n\nA description of the project th
 at Katie will present is provided below.\n\nThough angiogenesis (the gro
 wth of new blood vessels from pre-existing ones) must carefully unfold o
 ver time to generate functional\, well-adapted branching networks\, we s
 eldom hear about the time-based properties of angiogenesis\, despite tim
 ing being central to other areas of biology. \n\nWe developed a novel\, 
 time-based formulation of endothelial cell behaviour during angiogenesis
  and through our collection of recent integrated in silico/in vivo studi
 es we have demonstrate that various alterations to cell or tissue condit
 ions act to locally adapt the timing of collective cell decisions and be
 haviours\, impacting when certain cells decide to move\, and generating 
 a different spacing of vessel branches in the growing network. We are ca
 lling these ‘temporal regulators’ or ‘temporal adaptors’ of blood vessel
  branch spacing and they represent an exciting potential to externally m
 odulate vessel branching under different conditions. As such we are now 
 investigating them further and their potential as therapeutic targets to
  normalize vessel growth in disease. \n \n\nThe talk will be also be str
 eamed via Teams\, please contact carl.whitfield@manchester.ac.uk or igor
 .chernyavsky@manchester.ac.uk for the link\, or sign up to the mailing l
 ist.\n\nTo subscribe to the mailing list for this event series\, please 
 send an e-mail with the phrase “subscribe math-lifesci-seminar” in the m
 essage body to listserv@listserv.manchester.ac.uk
STATUS:TENTATIVE
TRANSP:TRANSPARENT
CLASS:PUBLIC
LOCATION:3.62\, Simon Building\, Manchester
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