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METHOD:PUBLISH
BEGIN:VEVENT
DTSTAMP:20251003T100858Z
DTSTART:20251014T120000Z
DTEND:20251014T130000Z
SUMMARY:Advances in Biosciences Seminar Series - Professor Roberto Mayor\
 , University College London (UCL)
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DESCRIPTION:Join the Division of Molecular and Cellular Function (MCF) fo
 r the Advances in Biosciences Seminar Series\, the speaker is Professor 
 Roberto Mayor\, University College London (UCL).\n\nHosted by Dr Ximena 
 Soto.\n\nTitle: “Chemo-mechanical Interplay in Embryonic Development”\n\
 nAbstract: Over the past century\, most research on embryo development h
 as focused on the role of genes and signaling pathways in this process. 
 However\, recent evidence indicates that other factors\, such as mechani
 cal cues\, also play a crucial role. In this seminar\, I will discuss th
 e role of mechanics in embryonic induction.\n\nAlthough embryonic induct
 ion was discovered over a century ago (Spemann and Mangold\, 1924)\, its
  molecular basis has only been elucidated in the last three decades with
  the identification of many inducers. However\, identifying inductive mo
 lecules is only half of the challenge. Crucially\, embryonic induction a
 lso requires tissues to be responsive to the inductive signals they rece
 ive (a property known as embryonic competence)\, a topic that has been l
 argely overlooked.\n\nSo far\, research has focused on the molecular reg
 ulators of competence\, while the role of mechanics as a potential regul
 ator has remained unexplored. We have demonstrated that the neural crest
  inductive signal (Wnt) is modulated by the mechanotransducer Yes-Associ
 ated Protein (YAP)\, revealing how mechanical and biochemical cues inter
 act to regulate embryonic competence. To highlight the universality of o
 ur findings\, we showed that this mechanism operates not only in Xenopus
  embryos but also in human-induced neural crest cells.\n\nSpeaker Bio: R
 oberto Mayor is a distinguished developmental biologist known for pionee
 ring research on cell migration in embryonic development. Born in Chile\
 , he earned his PhD studying mouse embryo development before conducting 
 postdoctoral research in London. Now a Professor at University College L
 ondon (UCL)\, his work on neural crest development has broad implication
 s\, including in cancer research. Dr. Mayor has received numerous honors
 \, including HHMI International Scholar\, EMBO membership and Fellow of 
 the Academy of Medical Sciences. He is Editor-in-Chief of Cells & Develo
 pment and Gene Expression Patterns and is dedicated to mentoring future 
 scientists through extensive teaching and supervision.\n\n\n\n
STATUS:TENTATIVE
TRANSP:TRANSPARENT
CLASS:PUBLIC
LOCATION:Michael Smith Lecture Theatre\, Michael Smith Building\, Manches
 ter
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