BEGIN:VCALENDAR
PRODID:-//Columba Systems Ltd//NONSGML CPNG/SpringViewer/ICal Output/3.3-
 M3//EN
VERSION:2.0
CALSCALE:GREGORIAN
METHOD:PUBLISH
BEGIN:VEVENT
DTSTAMP:20261023T090554Z
DTSTART:20261105T160000Z
DTEND:20261105T170000Z
SUMMARY:COEH Online Semiinar Series: Sleep and health in extreme environm
 ents: adaptation is the word - Prof Pierluigi Cocco
UID:{http://www.columbasystems.com/customers/uom/gpp/eventid/}yee-mvkqw3v
 4-oldxl
DESCRIPTION:Prolonged stay in Isolated\, Confined\, and Extreme (ICE) env
 ironments\, where the regular light/dark cycle is absent\, can induce sl
 eep deprivation and a cascade of adverse mental and physical health effe
 cts. An ongoing research project among the overwintering crew at the Con
 cordia research station in Antarctica is investigating which genetic and
  epigenetic mechanisms may support human adaptation under these exceptio
 nal conditions.\n\nThe Circadian rhythm adaptation in extreme environmen
 ts (CIRCADAPT) project is one of eight research initiatives selected by 
 the European Space Agency\, to which 11 of the 12 overwintering crew mem
 bers spending 12 months at the Concordia Station are participating. The 
 base presents a challenging setting\, characterised by extremely low tem
 peratures (reaching –90?°C during the Antarctic winter)\, the absence of
  a light–dark cycle for roughly two-thirds of the year\, hypobaric hypox
 ia due to the station’s altitude (3233?m)\, and complete physical isolat
 ion from other human settlements. No other life form is present in the s
 urroundings.\n\nThe study protocol comprises blood\, saliva\, and urine 
 sampling\; electrocardiographic\, actigraphic\, and polysomnographic mon
 itoring\; and self-administered questionnaires assessing daytime somnole
 nce\, sleep quality\, chronotype\, and mental well-being. Assessments ar
 e conducted before departure\, then after one\, three\, six\, and nine m
 onths in Antarctica\, and finally upon return at the end of the mission.
 \n\nThe genetic profile and methylome changes will be characterised in b
 lood samples\, enabling the identification of genomic variants and epige
 netic modifications associated with adaptation to ICE conditions. The ci
 rcadian rhythm of melatonin and cortisol secretion will be assessed thro
 ugh serial saliva sampling\, and biomarkers of oxidative stress will be 
 quantified in urine samples. Instrumental measurements will be matched w
 ith biological monitoring\, genetic polymorphism analyses\, and question
 naire-derived indicators to construct the overall picture of physiologic
 al\, behavioural\, and molecular adaptation throughout the overwintering
  period.\n\nThe results of an exploratory analysis of questionnaire data
 \, comparing perceived sleep quality and daytime somnolence after one mo
 nth in Antarctica with baseline values collected before departure\, will
  be presented.\n  \nPlease register for the event online. You will be se
 nt joining details after registration: https://events.teams.microsoft.co
 m/event/4c503d30-5f54-42f7-8679-3efdde21dac2@c152cb07-614e-4abb-818a-f03
 5cfa91a77
STATUS:TENTATIVE
TRANSP:TRANSPARENT
CLASS:PUBLIC
LOCATION:Online via MS teams
END:VEVENT
END:VCALENDAR