BEGIN:VCALENDAR
PRODID:-//Columba Systems Ltd//NONSGML CPNG/SpringViewer/ICal Output/3.3-
 M3//EN
VERSION:2.0
CALSCALE:GREGORIAN
METHOD:PUBLISH
BEGIN:VEVENT
DTSTAMP:20150522T120653Z
DTSTART:20150616T120000Z
DTEND:20150616T130000Z
SUMMARY:Mechanisms underlying ECM deposition and function in liver fibros
 is
UID:{http://www.columbasystems.com/customers/uom/gpp/eventid/}a45-i9zkaxb
 i-3d69vm
DESCRIPTION:Liver fibrosis is characterized by the accumulation of extrac
 ellular matrix (ECM) proteins or scar which destroys normal tissue archi
 tecture. This plays a major role in the pathogenesis and progression of 
 liver fibrosis. Identifying core regulators of ECM deposition and functi
 on may lead to urgently needed diagnostic and therapetic strategies for 
 the disease. To address this\, my lab has identified the transcription f
 actor\, Sex determining region Y box 9 (SOX9)\, is ectopically expressed
  and increased in liver fibrosis.  In his talk I will present data showi
 ng how the profibrotic environment influences SOX9 to regulate the produ
 ction of ECM and how its prevalence in humans is indicative of progressi
 ve liver fibrosis. I will also provide evidence of how SOX9-regulate ECM
  promotes profibrotic features of hepatic myofibroblasts (a major source
  of ECM) through integrin-dependent intracellular mechanisms and how pha
 rmacologically targeting this represents new therapeutic treatments for 
 liver fibrosis.
STATUS:TENTATIVE
TRANSP:TRANSPARENT
CLASS:PUBLIC
LOCATION:Michael Smith Lecture Theatre\, Michael Smith Building\, Manches
 ter
END:VEVENT
END:VCALENDAR