Special seminar: The cardiac microenvironment and the challenges to mend a broken heart
| Dates: | 12 July 2018 |
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| Times: | 10:00 - 11:00 |
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| What is it: | Seminar |
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| Organiser: | Faculty of Biology, Medicine and Health |
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| Who is it for: | University staff |
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| Speaker: | Jose Krieger |
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“Replacing damaged tissue following a myocardial infarction remains a challenge. Several strategies using gene/cell approaches have been explored in recent years with limited success. In this context, human induced pluripotent stem cells derived cardiac cells (hiPSC-CMs) appear quite appealing since they present many advantages such as the ability to self-renew indefinitely, to differentiate into the desired cell types including cardiomyocytes, and they could be generated in a patient-specific way, opening the door to personalized medicine. There is also evidence that transplantation of adult stem cells is beneficial even though in the absence of cardiac generation, which raises the possibility to enhance neo-angiovasculogenesis, decrease inflammation and to target the extracellular matrix to produce a scar with properties that are more amenable to sustain the mechanical properties of the heart. In the discussion, we will focus on the challenges to harness these interventions to increase the therapeutic potential of cardiac repair/regeneration post-MI.”
Speaker
Jose Krieger
Role: Director
Organisation: Heart Institute (InCor), Sao Paulo
Travel and Contact Information
Find event
1.006
AV Hill Building
Manchester
