Electrophysiological Markers of Neurodegenerative Disease and Sleep/Wake Quality
| Dates: | 21 July 2015 |
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| Times: | 13:00 - 13:00 |
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| What is it: | Seminar |
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| Organiser: | Faculty of Life Sciences |
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| Speaker: | Simon Fisher |
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This Seminar is part of the Future Leaders series. Abstract: A major challenge facing late-onset neurodegenerative conditions is determination of the initiation and progression of the disease prior to symptom onset and before significant neuronal loss. Therefore, it is critical to identify early-stage markers that can reliably detect and track the disease. The electroencephalogram (EEG) and sleep/wake architecture were investigated longitudinally across two murine models of Huntington’s disease (HD), an inherited neurodegenerative disorder. Across these models, expression of the HD mutation resulted in common EEG alterations and sleep abnormalities that worsened with disease development. Collectively, this suggests that these electrophysiological markers may be valuable indicators of HD disease onset and progression with significance for other neurodegenerative diseases. Electrophysiological markers can also provide important information relating to sleep/wake quality. Definitions of sleep quality are often based on subjective measures and despite its high clinical relevance in the diagnosis of sleep disorders this concept has not been rigorously defined. Our ongoing work is using cortical multi-unit neuronal activity and EEG in wildtype mice to investigate more objective markers of sleep/wake quality, based on the recent concept that sleep and waking are not global all-or-none phenomena but that they have a local component.
Speaker
Simon Fisher
Organisation: University of Oxford
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4.005
AV Hill Building
Manchester
