BEGIN:VCALENDAR
PRODID:-//Columba Systems Ltd//NONSGML CPNG/SpringViewer/ICal Output/3.3-
 M3//EN
VERSION:2.0
CALSCALE:GREGORIAN
METHOD:PUBLISH
BEGIN:VEVENT
DTSTAMP:20230509T123038Z
DTSTART:20230512T120000Z
DTEND:20230512T130000Z
SUMMARY:Centre for Biological Timing Seminar - Systems Biology of Human S
 leep/Wake Cycles: Phosphorylation Hypothesis of Sleep by Professor Hirok
 i Ueda (University of Tokyo and RIKEN)
UID:{http://www.columbasystems.com/customers/uom/gpp/eventid/}c1h9-lhg77u
 lh-7dwds9
DESCRIPTION:Systems Biology of Human Sleep/Wake Cycles: Phosphorylation H
 ypothesis of Sleep by Professor Hiroki Ueda\, the University of Tokyo an
 d RIKEN\, Japan. \n\n[https://documents.manchester.ac.uk/display.aspx?Do
 cID=67279 Further details can be found on the event flyer]\n\nSpeaker bi
 o\n\nProfessor Hiroki R. Ueda\, graduate school of medicine\, The Univer
 sity of Tokyo. \n\nHe graduated from the Faculty of Medicine\, the Unive
 rsity of Tokyo in 2000\, and obtained his Ph.D. in 2004 from the same un
 iversity. He was appointed as a team leader in RIKEN in 2003. He became 
 a full professor in Graduate School of Medicine\, the University of Toky
 o in 2013. In 2016\, he found the first sleep-promoting kinases\, CaMKII
 alpha and CaMKIIbeta and proposed phosphorylation hypothesis of sleep th
 at phosphorylation-dependent regulation of Ca2+-dependent hyperpolarizat
 ion pathway underlies the regulation of sleep homeostasis in mammals. In
  2018\, he also found the first essential genes of REM sleep\, muscarini
 c receptors M1 and M3. To accelerate these studies\, he also invented wh
 ole-brain and whole-body clearing and imaging methods called CUBIC as we
 ll as the next-generation mammalian genetics such as Triple-CRISPR and E
 S-mice methods for one-step production and analysis of KO and KI mice wi
 thout crossing.
STATUS:TENTATIVE
TRANSP:TRANSPARENT
CLASS:PUBLIC
LOCATION:Michael Smith Lecture Theatre\, Michael Smith Building\, Manches
 ter
END:VEVENT
END:VCALENDAR