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METHOD:PUBLISH
BEGIN:VEVENT
DTSTAMP:20250203T163405Z
DTSTART:20250213T120000Z
DTEND:20250213T130000Z
SUMMARY:BSI Manchester Immunology Group Seminar Series:  Dr David Bending
 \, University of Birmingham. Location: MS Lecture Theatre\, Michael Smit
 h Building
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DESCRIPTION:Talk title: Regulation of NFAT signalling in CD4+ T cells\n\n
 Brief lab biography:\n\nOur research focuses on how TCR signalling regul
 ates T cell biology. My lab has interests in understanding how immunothe
 rapy can alter T cell activation and identify favourable T cell signatur
 es of therapy responders. We have developed cutting-edge TCR signalling 
 research tools\, such as the Timer rapidly expressed in lymphocytes (Tem
 po) mice\, to study T cell activation. Recent major findings are i) the 
 discovery of the “TCR.strong” signalling signature\, which is a hallmark
  of effective T cell responses to anti-PD1 immunotherapy\; and ii) that 
 anti-Lag3 and anti-PD-1 combination therapy drives distinct NFAT-depende
 nt TCR signalling programmes. Our vision is that through gaining a deepe
 r mechanistic understanding of checkpoint biology\, we can use this know
 ledge to inform precision medicine strategies. \n\n
STATUS:TENTATIVE
TRANSP:TRANSPARENT
CLASS:PUBLIC
LOCATION:Michael Smith Lecture Theatre\, Michael Smith Building\, Manches
 ter
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