3D mode Systems for Mineralised Tissue Regeneration and Understanding Dental Pulp Stem Cell Behaviour
| Dates: | 17 June 2016 |
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| Times: | 14:00 - 15:00 |
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| What is it: | Seminar |
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| Organiser: | Faculty of Life Sciences |
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| Who is it for: | University staff, Current University students |
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| Speaker: | Professor Alastair Sloan |
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Mineralised matrices contain reservoirs of bioactive molecules capable of directing tissue repair. Elucidating the release mechanisms of such endogenous growth factors will enhance our understanding of bone healing and regeneration and support the development of novel treatment modalities to enhance bone repair following trauma, disease or surgery. To this end, there is a need for better effective methods of assessing therapeutic approaches to improving bone repair at the cellular and gross tissue level. Experimental modelling of bone regeneration, inflammatory bone destruction and the factors influencing matrix secretion is hampered by the lack of suitable models. Whilst in vivo, and in vitro systems may be limiting , ex vivo organotypic cultures, whereby cells and tissues are cultured in situ may provide a more suitable model system. From a regeneration viewpoint, it is widely accepted that progenitor/stem cells reside within the post-natal dental pulp and studies suggest several niches of mesenchymal progenitor cells may be present. Understanding the nature of these progenitor cell populations, their ability to function in highly compromised environments and determination of their potentialities in terms of specificity of regenerative response may facilitate their potential use in clinical therapies.
Speaker
Professor Alastair Sloan
Organisation: Cardiff University
Travel and Contact Information
Find event
Michael Smith Lecture Theatre
Michael Smith Building
Manchester
