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METHOD:PUBLISH
BEGIN:VEVENT
DTSTAMP:20240917T104209Z
DTSTART:20240930T120000Z
DTEND:20240930T130000Z
SUMMARY:Professor Dirk Linke\, Department of Biosciences\, University of 
 Oslo\, Norway. Hosted by Dr Christos Pliotas
UID:{http://www.columbasystems.com/customers/uom/gpp/eventid/}cqg-m16b1de
 k-rpievc
DESCRIPTION:Please join us for a seminar hosted by Dr Christos Pliotas. \
 n\nTitle: "Autotransporter adhesins in Gram-negative bacteria: structure
 \, function\, evolution"\n\nSummary: Autotransporters - or Type V secret
 ion systems - are simple secretion systems that translocate surface prot
 eins across the outer membrane of Gram-negative bacteria. Mostly\, these
  proteins then remain anchored in the membrane and fulfil key functions 
 in pathogenesis. Some of the major adhesins of Gram-negative human patho
 gens are part of this large family\, mediating attachment to host cells 
 and/or initiating biofilm formation. \nOver the last years\, my group ha
 s been working on both the translocation mechanism across the membrane\,
  and the binding functions of select type-V-secreted adhesins. We use a 
 broad range of methods from infection biology to bioinformatics and NMR.
  Our model systems include both human and animal pathogens - we try to l
 earn from the similarities and differences of their adhesin virulence fa
 ctors\, aiming to understand what defines host specificity\, and how adh
 esion could be used as a target for new antibacterial drugs. \n
STATUS:TENTATIVE
TRANSP:TRANSPARENT
CLASS:PUBLIC
LOCATION:Michael Smith Lecture Theatre\, Michael Smith Building\, Manches
 ter
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