The next seminar in the ‘Celebrating Research Success in FLS’ series will be given by Prof James McInerney who is a member of the Computational and Evolutionary Biology Research Theme. The seminar is scheduled to take place just prior to FLS Happy Hour to allow discussions and networking to continue after the actual presentation.
James presentation will be entitled ‘Integrating different "Omics" data to understand Eukaryote Origins’ and he will speak about the following publications:
• Ku, C., Nelson-Sathi, S., Roettger, M., Sousa, F.L., Lockhart, P., Bryant, D., Hazkani-Covo,E., McInerney, J.O., Landan, G., and Martin, W.F. (2015). Endosymbiotic origin and differential loss of eukaryotic genes. Nature. 524, 427–432.
• McInerney, J.O., O’Connell, M.J., Pisani, D. (2014). The hybrid nature of the Eukaryota and a consilient view of life on Earth. Nature Reviews Microbiology. 12(6):449-55.
• Alvarez-Ponce, D., Lopez, P., Bapteste, E., McInerney, J.O. (2013). Gene similarity networks provide new tools for understanding eukaryote origins and evolution. Proceedings of the National Academy of Sciences USA. 110(17):E1594-603.
• Cotton, J.A., and McInerney, J.O. (2010) Eukaryotic genes of archaebacterial origin are more important than the more numerous eubacterial genes, irrespective of function. Proceedings of the National Academy of Sciences, USA 107(40):17252-17255.
Over the past five years, our understanding of eukaryote origins has undergone a transformation. Eukaryote genomes are a clear hybrid of eubacterial and archaebacterial genes. Eukaryote protein interaction networks are stratified along the lines of their evolutionary history and eukaryote gene essentiality, centrality in protein interaction networks, evolutionary rate, likelihood of involvement in mendelian disease are all linked to their evolutionary history.