BEGIN:VCALENDAR
PRODID:-//Columba Systems Ltd//NONSGML CPNG/SpringViewer/ICal Output/3.3-
 M3//EN
VERSION:2.0
CALSCALE:GREGORIAN
METHOD:PUBLISH
BEGIN:VEVENT
DTSTAMP:20180912T090103Z
DTSTART:20181005T120000Z
DTEND:20181005T130000Z
SUMMARY:CMB&RM seminar: Exploitation of the LRG1-regulated TGF? signaling
  in cardiovascular diseases: a doubled-edged sword?
UID:{http://www.columbasystems.com/customers/uom/gpp/eventid/}d11z-jlyx0u
 b3-ytuvq8
DESCRIPTION:Xiaomeng is interested in the role of TGF? signalling in deve
 lopment and under disease conditions. Her earlier work demonstrated that
  type IV collagen not only function as an affinity matrix for binding an
 d immobilizing TGF? family growth factor\, Decapentaplegic (Dpp)\, but a
 lso regulates its signalling during Drosophila development. Her recent s
 tudy led to the identification of another novel regulator of TGF? signal
 ling\, Leucine rich alpha 2 glycoprotin 1 (Lrg1). This work revealed for
  the first time the function and molecular mechanism of Lrg1 regulated T
 GF? signalling in pathological angiogenesis and raised the intriguing po
 ssibility of targeting Lrg1 as a novel treatment for diseases such as di
 abetic vascular complications\, cancer\, atherosclerosis and rheumatoid 
 arthritis. Both studies have been published in Nature as an article.?
STATUS:TENTATIVE
TRANSP:TRANSPARENT
CLASS:PUBLIC
LOCATION:Lecture Theatre\, Michael Smith Building\, Manchester
END:VEVENT
END:VCALENDAR