James E. Moore Jr -- Challenges in Quantifying Lymphatic System Transport and Immune Cell Trafficking [IN PERSON]
|Starts:||14:00 14 Nov 2022|
|Ends:||15:00 14 Nov 2022|
|What is it:||Seminar|
|Organiser:||Department of Mathematics|
|Who is it for:||University staff, External researchers, Current University students|
|Speaker:||James E. Moore Jr|
Join us for this seminar by Jimmy Moore (Imperial) as part of the North West Seminar Series in Mathematical Biology and Data Sciences. Details of the full series can be found here https://www.cms.livjm.ac.uk/APMSeminar/
The talk will be hosted in person in the Simon Building, Room 4.38. For those who cannot attend in person the talk will also be streamed via zoom, please contact firstname.lastname@example.org or email@example.com for the zoom link, or sign up to the mailing list.
Talk title: Challenges in Quantifying Lymphatic System Transport and Immune Cell Trafficking
Abstract: In addition to its role in fluid balance, the lymphatic system serves as a communication system for immune function. Antigens and cells of many types (including cancer cells) enter the system and are transported by actively pumping collecting lymphatic vessels to lymph nodes. These fascinating organs provide carefully structured zones of specific cell types, specialised blood vessels and fluid flow-mediated processes that affect many functions in health and disease. Cell migration to and through lymph nodes is crucial for immune response and adaptive immunity. Assessing cell migration is generally tied to an assumption that modern imaging techniques permit imaging parameters where the resulting cell track accurately captures a cells motion. However, the relationship between what could be observed at a given scale and the underlying cell behaviour often remains undefined. Insufficient spatial and temporal resolutions within migration assays can result in misrepresentation of important physiologic processes or cause subtle changes in critical cell behaviour to be missed. We have contextualised how scale can affect the perceived migratory behaviour of cells, summarise the limited approaches to mitigate this effect, and establish the need for a widely implemented framework to account for scale and correct observations of cell motion. We then extend the concept of scale to new approaches that seek to bridge the current “black box” between single cell behaviour and systemic response.
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James E. Moore Jr
Organisation: Imperial College London
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