Kat Coyte - From stability to assembly: understanding the dynamic microbiome
|Dates:||21 October 2019|
|Times:||14:00 - 14:50|
|What is it:||Seminar|
|Organiser:||Department of Mathematics|
|Who is it for:||University staff, External researchers, Current University students|
(Room 3.62 Simon Building)
Join us for this seminar by Kat Coyte (Manchester) as part of the Mathematics in the Life Sciences Series.
Abstract: Mammalian guts harbour diverse microbial communities that are vital for host health. These communities gradually assemble after birth and shift, sometimes irreversibly, in response to antibiotics. Yet despite their importance, we understand little about how and why microbiota change over time. Here I will discuss recent work identifying drivers of microbiota dynamics within preterm infants. Applying ecological tools to longitudinal samples from ~200 infants, we identify a set of within- and between-kingdom microbial interactions that appear to shape microbiota assembly. Early arrivals promote other microbes colonizing the gut, while specific fungal taxa inhibit dominant bacteria. These interactions, derived computationally, can be independently recapitulated in both in vitro and in vivo models. Our work underlines the importance of microbial interactions in shaping microbiota dynamics and highlights the role of non-bacterial microbes within the gut. More fundamentally, we illustrate how ecological theory can be combined with clinical data and simple experiments to interrogate microbial communities.
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Role: Presidential Fellow
Organisation: University of Manchester
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