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PRODID:-//Columba Systems Ltd//NONSGML CPNG/SpringViewer/ICal Output/3.3-
 M3//EN
VERSION:2.0
CALSCALE:GREGORIAN
METHOD:PUBLISH
BEGIN:VEVENT
DTSTAMP:20160318T142636Z
DTSTART:20160506T140000Z
DTEND:20160506T150000Z
SUMMARY:Celebrating Research Success in FLS Seminar - Membrane Type I-Mat
 rix Metalloproteinase 14 - a pericellular collagenase and tissue archite
 ct all rolled up in one 
UID:{http://www.columbasystems.com/customers/uom/gpp/eventid/}e1jl-ilxsmb
 zp-lzk1n8
DESCRIPTION:The next seminar in the ‘Celebrating Research Success’ series
  will be given by Prof Karl Kadler who is a member of the Cell Matrix Bi
 ology Research Theme. The seminar is scheduled to take place just prior 
 to FLS Happy Hour to allow discussions and networking to continue after 
 the actual presentation.\n\nKarl’s presentation will be entitled ‘Membra
 ne Type I-Matrix Metalloproteinase 14 - a pericellular collagenase and t
 issue architect all rolled up in one’ and will focus on one of his publi
 cations: \n•	Taylor SH\, Yeung CYC\, Kalson NS\, Lu Y\, Zigrino P\, Star
 borg T\, Warwood S\, Holmes DF\, Canty-Laird EG\, Mauch C\, Kadler K. (2
 015). Matrix metalloproteinase 14 is required for fibrous tissue expansi
 on. eLife 2015\;10.7554/eLife.09345\n\nAbstract\n\nMembrane type I-matri
 x metalloproteinase (MT1-MMP\, encoded by mmp14) is well known for its a
 bility to cleave collagen in vitro.  However\, we were curious why the k
 nockout mouse had fragile tissues and was smaller than its wild-type lit
 termates.  It didn’t make sense that missing a major collagenase would r
 esult in thin and weak tissues.  Even more curious was the fact that the
  collagenase-resistant mouse (Col-r/r) has the opposite phenotype to the
  mmp14 knockout mouse and is severely fibrotic\, as expected. In this pa
 per we go against dogma and show that MT1-MMP is essential for tissue ex
 pansion in the embryo\, and catalyses the switch from embryonic to adult
  fibrous tissue assembly. Without MT1-MMP\, the embryo is ‘stuck’ in the
  embryonic state.     \n\n
STATUS:TENTATIVE
TRANSP:TRANSPARENT
CLASS:PUBLIC
LOCATION:Michael Smith LT\, Michael Smith Building\, Manchester
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