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PRODID:-//Columba Systems Ltd//NONSGML CPNG/SpringViewer/ICal Output/3.3-
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CALSCALE:GREGORIAN
METHOD:PUBLISH
BEGIN:VEVENT
DTSTAMP:20160330T074118Z
DTSTART:20160406T120000Z
DTEND:20160406T130000Z
SUMMARY:Redox Regulation of Chondrocyte Integrin Signaling and Osteoarthr
 itis
UID:{http://www.columbasystems.com/customers/uom/gpp/eventid/}e1l0-imejn0
 e1-xfoqvj
DESCRIPTION:Richard is Director of Basic and Translational Research in th
 e Thurston Arthritis Research Center at Chapel Hill\, North Carolina.\n\
 nAbstract : Osteoarthritis results from degradation of joint tissues inc
 luding the articular cartilage. Chondrocytes are the only cell type pres
 ent in cartilage and are responsible for both synthesis and degradation 
 of the cartilage matrix. As the cartilage ECM is degraded\, fragments of
  ECM proteins\, including fibronectin fragments that bind the ?5?1 integ
 rin are generated. Unlike intact fibronectin\, fibronectin fragments act
 ivate cell signaling pathways that upregulate expression of a host of MM
 Ps\, cytokines\, and chemokines that promote progressive matrix destruct
 ion in a positive feedback fashion. Our most recent studies have focused
  on the redox regulation of chondrocyte signaling through oxidative post
 translational modification of reactive cysteine residues in specific sig
 naling proteins through a process known as protein sulfenylation. These 
 studies are helping to identify key steps in fibronectin fragment-induce
 d signaling that will lead to new targets to stop the progressive destru
 ction of cartilage and other joint tissues in OA.
STATUS:TENTATIVE
TRANSP:TRANSPARENT
CLASS:PUBLIC
LOCATION:Lecture Theatre\, Michael Smith Building\, Manchester
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