Genetic stability and fate determination in human pluripotent stem cells
| Dates: | 12 December 2014 |
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| Times: | 14:00 - 15:00 |
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| What is it: | Seminar |
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| Organiser: | Faculty of Life Sciences |
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| Who is it for: | University staff, Current University students |
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| Speaker: | Peter Andrews |
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This seminar is part of the Manchester Tissue Regeneration & Stem Cell Network seminar series. Pluripotent stem cells are characterized by their capacity to self renew or to initiate differentiation leading to the appearance of cells of all three gem layers. Understanding the mechanisms by which these cells make fate decisions is central to their eventual use in a wide range of applications, including regenerative medicine. Recent work has indicated that such pluripotent stem cells may exist in interconvertible substates that exhibit differential propensities for specific fate decisions. At the same time, other work indicates that they may acquire non-random genetic change because such mutations provide variant cells with a selective growth advantage arising from altered patterns of differentiation. We are currently investigating whether these genetic variants influence differentiation by altering the dynamics of interconversion of stem cell substates.
Speaker
Peter Andrews
Organisation: University of Sheffield
Travel and Contact Information
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Lecture Theatre
Michael Smith Building
Manchester
