BEGIN:VCALENDAR
PRODID:-//Columba Systems Ltd//NONSGML CPNG/SpringViewer/ICal Output/3.3-
 M3//EN
VERSION:2.0
CALSCALE:GREGORIAN
METHOD:PUBLISH
BEGIN:VEVENT
DTSTAMP:20140114T171317Z
DTSTART:20140123T140000Z
DTEND:20140123T150000Z
SUMMARY:Hox genes and patterning brain development: A story in segments
UID:{http://www.columbasystems.com/customers/uom/gpp/eventid/}e75-hpe8wjw
 z-upp726
DESCRIPTION:This seminar is part of the Tissue Systems seminar series.   
                                                                         
                                                                         
                                                                         
              The vertebrate hindbrain is a highly conserved co-ordinatio
 n center where regional diversity and patterning of neurogenesis is achi
 eved through a process of segmentation. The Hox family of transcription 
 factors is coupled to this process and provides a molecular framework fo
 r specifying the unique identities of hindbrain segments (rhombomeres) a
 nd developing neurons. Through regulatory analyses utilizing BAC recombi
 neering\, transgenic mice and multispectral imaging\, mechanistic insigh
 t into how patterns of Hox expression are established in response to sig
 nals during mouse development is being generated. Genetic studies have s
 hown that Hox genes play roles in controlling rhombomere identity\, cran
 ial neural crest migration\, neuronal differentiation and facial nerve d
 evelopment. However\, very little is known about how Hox genes control d
 ownstream target genes to fulfill these roles.  Transcriptional profilin
 g of individual rhombomeres in wild type and mutant mice isolated by las
 er capture microscopy is uncovering genes and pathways under Hox regulat
 ion. To identity potential direct target genes\, genomic approaches in m
 ouse tissues and ES cells differentiated into neurons is revealing bindi
 ng regions of Hox proteins and their co-factors on a genome wide basis. 
  Through genomic\, developmental  and proteomic analyses we are gaining 
 insight on Hox target genes\,  Hox protein specificity and uncovering no
 vel interactions between Hox proteins and factors that underlie their fu
 nctional roles. This lecture will summarize progress on these fronts.
STATUS:TENTATIVE
TRANSP:TRANSPARENT
CLASS:PUBLIC
LOCATION:Lecture Theatre\, Michael Smith Building\, Manchester
END:VEVENT
END:VCALENDAR