Special Seminar: Antoine de Morree, Stanford University - 'Post-transcriptional Control of Muscle Stem Cell Function'
| Dates: | 7 February 2020 |
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| Times: | 11:30 - 12:30 |
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| What is it: | Seminar |
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| Organiser: | Faculty of Biology, Medicine and Health |
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| Who is it for: | University staff, Adults, Current University students |
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| Speaker: | Antoine de Morree |
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Antoine de Morree, Stanford University will present 'Post-transcriptional Control of Muscle Stem Cell Function'
Abstract:
Tissue regeneration depends on the timely activation of adult stem cells. In skeletal muscle, adult muscle stem cells exist in a reversible state of prolonged exit from the cell cycle, also known as quiescence.
Upon injury, these cells activate and enter the cell cycle to expand and make new muscle tissue. While the quiescent state is absolutely key to muscle stem cell function, little is known about how it is regulated. A major challenge has been the lack of tools to analyze quiescent stem cells in vivo, in their niche. We used muscle stem cell-specific labeling of RNA to investigate the transcriptome of quiescent muscle stem cells in vivo.
This new approach revealed the expression of differentiation genes for which the protein remained undetectable, indicating the importance of post-transcriptional regulation in muscle stem cell function. I identified the RNA-binding protein Staufen1 and the microRNA 206 as translational repressors important for maintaining quiescence. I will discuss two mechanisms of post-transcriptional control of muscle stem cell function and fate.
Speaker
Antoine de Morree
Organisation: Stanford University
Travel and Contact Information
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Michael Smith lecture theatre
Michael Smith Building
Manchester
