BEGIN:VCALENDAR
PRODID:-//Columba Systems Ltd//NONSGML CPNG/SpringViewer/ICal Output/3.3-
 M3//EN
VERSION:2.0
CALSCALE:GREGORIAN
METHOD:PUBLISH
BEGIN:VEVENT
DTSTAMP:20151210T122945Z
DTSTART:20151214T153000Z
DTEND:20151214T163000Z
SUMMARY:MCCIR AZ GSK Update Seminar Series
UID:{http://www.columbasystems.com/customers/uom/gpp/eventid/}eoz-ii082f7
 l-jkeg2a
DESCRIPTION:Mast cell-mediated regulation of T cell activities\n\nRajia B
 ahiri\n\nMast cells (MCs) are recognized to participate in the regulatio
 n of innate and adaptive immune responses. Owing to their strategic loca
 tion at the host–environment interface\, they control tissue homeostasis
  and are key cells for starting early host defense against intruders. Up
 on degranulation induced\, e.g.\, by immunoglobulin E (IgE) and allergen
 -mediated engagement of the high-affinity IgE receptor\, complement or c
 ertain neuropeptide receptors\, MCs release a wide variety of preformed 
 and newly synthesized products. Mast cell activation is associated with 
 atopic diseases. Interestingly\, increasing evidence suggests a regulato
 ry role for MCs in inflammatory diseases via the regulation of T cell ac
 tivities. Our work focus on the regulatory effect of Mast cells on T cel
 ls. We have demonstrated that MCs induced antigen-specific CD8+ T cell a
 ctivation and proliferation. This process required direct cell contact a
 nd MHC class I-dependent antigen cross-presentation by MCs and induced t
 he secretion of cytokine and increased their cytotoxicity. Furthermore\,
  MC can also induce antigen specific activation and proliferation of CD4
 + T cells. In addition\, upon cytokine treatment mast cells expressed mo
 lecules that could be involved in stimulation or co-stimulation of immun
 e cell. Thus\, rather than only serving as effector cells\, MCs are impo
 rtant players in regulation of T cells.\n\nUnderstanding the roles of Ma
 st Cell proteases in skin inflammation\n\nMichelle Campbell\n\nMast cell
 s have principally been viewed in the context of allergy\; however\, rec
 ent findings implicate mast cells in both the homeostasis and pathophysi
 ology of the skin\, including psoriasis a disease in which mast cells ar
 e implicated. As cells with the capacity to both degranulate quickly to 
 release pre-formed mediators and to de novo synthesise both pro and infl
 ammatory mediators the way in which mast cells contribute to modulating 
 their surroundings is an area of ongoing research. One of the main const
 ituents produced by mast cells are proteases of the tryptase\, chymase a
 nd elastase substypes. These proteases are released upon degranulation a
 s soluble mediators\, with the exception of transmembrane tryptase gamma
  (TMT?\, TPSG1\, Prss31)\, which is expressed on the cell surface and po
 tentially shed. Soluble mast cell proteases are already known to be impo
 rtant in pathological conditions at other sites\, with mouse mast cell p
 rotease-1 (mMCP-1)\, a chymase\, being critical to worm expulsion in the
  Trichinella spiralis mouse model (1) and mMCP-6 and -7\, tryptases\, be
 ing implicated in the mBSA/IL-1? model of arthritis (2).  Furthermore\, 
 the membrane bound tryptase\, TMT?\, has recently been shown to be detri
 mental in both the dextran sodium-sulfate (DSS) model of colitis and the
  cigarette smoke induced model of chronic obstructive pulmonary disease 
 (COPD) (3). Specifically in the skin\, in human psoriasis\, both the num
 ber and activity of mast cells are increased in psoriatic lesions (4). W
 e are therefore interested in delineating the roles of mast cell proteas
 es in both homeostasis and in inflammatory situations in the skin\, whil
 st also determining the role of TMT? both in vitro and in vivo. \n
STATUS:TENTATIVE
TRANSP:TRANSPARENT
CLASS:PUBLIC
LOCATION:Michael Smith Lecture Theatre\, Michael Smith Building\, Manches
 ter
END:VEVENT
END:VCALENDAR