Ernesto Berríos-Caro -- Bottleneck size and antibiotic-induced selection impact antibiotic resistance evolution
|Starts:||14:00 7 Mar 2022|
|Ends:||15:00 7 Mar 2022|
|What is it:||Seminar|
|Organiser:||Department of Mathematics|
|Who is it for:||University staff, External researchers, Current University students|
Join us for this seminar by Ernesto Berríos-Caro (Max Planck Institute) as part of the North West Seminar Series in Mathematical Biology and Data Sciences. Details of the full series can be found here https://www.cms.livjm.ac.uk/APMSeminar/
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Abstract: During antibiotic treatment, the evolution of bacterial pathogens is fundamentally affected by population-genetic characteristics, such as population size and population bottlenecks. Bottlenecks—that is, drastic reductions in bacterial population size—lead to an increased influence of random effects (genetic drift) during bacterial evolution, and varying antibiotic concentrations during treatment may favour distinct resistance variants. Bacterial populations undergo several bottlenecks during infection of host populations, imposed by the transmission of pathogens between hosts, the host immune system, or the antibiotic treatment employed. Despite the relevance and likely presence of bottlenecks in antibiotic resistance evolution, their effect, along with other relevant factors (e.g., antibiotic-induced selection, competition, clonal interference), has been largely ignored in the literature. Evolution experiments conducted by Dr. Hinrich Schulenburg et al. (https://doi.org/10.1038/s41559-021-01511-2) have demonstrated that bottleneck size and antibiotic-induced selection reproducibly impact the evolutionary path to resistance in pathogenic Pseudomonas aeruginosa. In particular, they found that resistance is favoured—expectedly—under high antibiotic selection and weak bottlenecks, but—unexpectedly—also under low antibiotic selection and severe bottlenecks. In this talk, I will present preliminary results on the theoretical modelling of these experiments to explain this phenomenon. The model I will discuss is based on a competitive multi-strain Lotka-Volterra model with Baranyi growth.
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Role: Postdoctoral Researcher
Organisation: Max Planck Institute for Evolutionary Biology
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