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 M3//EN
VERSION:2.0
CALSCALE:GREGORIAN
METHOD:PUBLISH
BEGIN:VEVENT
DTSTAMP:20151210T121152Z
DTSTART:20151214T143000Z
SUMMARY:Centre for Biostatistics Seminar: Identification of causal genes 
 of immune-mediated diseases using statistical colocalisation 
UID:{http://www.columbasystems.com/customers/uom/gpp/eventid/}foy-ii07czv
 2-w21tud
DESCRIPTION:'''Host:''' Institute of Population Health\n\n'''About the ev
 ent:'''\n\nThe next Centre for Biostatistics seminar is taking place Mon
 day 14th December at 2.30 pm in G306B Jean McFarlane Building. The speak
 er will be Hui Guo.\n\nTitle: ''From association to causation: identific
 ation of causal genes of immune-mediated diseases using statistical colo
 calisation''\n\n'''Abstract:'''\n\nAutoimmune diseases\, for example\, t
 ype 1 diabetes and rheumatoid arthritis\, are long-term diseases due to 
 abnormal immune responses of the bodies. To date\, hundreds of disease-a
 ssociated regions have been successfully identified through genome-wide 
 association studies (GWAS). Searching for shared causal signals becomes 
 an important part of research in genetics. Furthermore\, the mechanisms 
 of these associations mediated by genetic regulation is partially unders
 tood.\n\nStatistical colocalisation is a way to address such issues by i
 ntegrating results from different studies\, under certain assumptions. H
 ui Guo will give an overview of colocalisation methods where only summar
 y statistics are required. In particular\, the talk will focus on a Baye
 sian approach using approximate Bayes factor. Two examples will be discu
 ssed for applications: integrated analysis of disease association and ge
 ne expression\, and of associations of various autoimmune diseases.
STATUS:TENTATIVE
TRANSP:TRANSPARENT
CLASS:PUBLIC
LOCATION:G306B\, Jean McFarlane Building \, Oxford Rd\, Manchester\, M139
 PY
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