Cell cycle regulation of differentiation in development and disease
| Dates: | 8 May 2014 |
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| Times: | 12:00 - 13:00 |
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| What is it: | Seminar |
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| Organiser: | Faculty of Life Sciences |
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| Who is it for: | University staff, Current University students |
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| Speaker: | Anna Philpott |
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Abstract: It is essential that division and differentiation are carefully co-ordinated during development. We are investigating the molecular mechanisms by which the cell cycle machinery can directly control the activity of key transcription activators, the proneural proteins, which are responsible forregulating differentiation in the nervous system, pancreas and multiple other tissues. We see that proneural protein activity is regulated by multi-site phosphorylation driven by cell cycle kinases, and this differentially affects transcriptional activation of distinct downstream targets, altering the balance between proliferation and differentiation. Moreover, we explore important implications for this regulatory mechanism in development, regeneration and cancer biology.
Speaker
Anna Philpott
Organisation: University of Cambridge
Travel and Contact Information
Find event
Lecture Theatre
Michael Smith Building
Manchester
