Cellular injury driven changes in the integrin repertoire modulates YAP-dependent transcription in the kidney glomerulus
| Dates: | 1 December 2023 |
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| Times: | 13:00 - 14:00 |
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| What is it: | Seminar |
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| Organiser: | Faculty of Biology, Medicine and Health |
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| Who is it for: | University staff, Current University students |
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| Speaker: | Jordan Kreidberg |
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Our studies focus on the interplay between adhesion and transcriptional regulation. We use the kidney glomerulus and podocyte injury as a model to study how integrins affect the YAP and TAZ transcriptional effectors. Podocyte injury or loss of a3b1 integrin led to increased abundance of aVb5 integrin and nuclear localization of YAP. Additionally, loss of both YAP and TAZ in podocytes of adult mice rapidly compromised the glomerular filtration barrier. Increased glomerular expression of aV integrins was found in human kidney disease. Thus, our studies demonstrate the crucial regulatory interplay between cell adhesion and transcriptional regulation, and how this may be an important determinant of human disease.
Speaker
Jordan Kreidberg
Organisation: Beth Israel Deaconess Medical Center, Boston
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Lecture Theatre
Michael Smith Building
Manchester
