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Microglia priming in neurodegenerative disease |The impact of systemic inflammation

Dates:5 March 2014
Times:16:00 - 17:00
What is it:Seminar
Organiser:Neuroscience Research Institute
Who is it for:Current University students, University staff
Speaker:Prof V. Hugh Perry
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  • In category "Seminar"
  • By Neuroscience Research Institute

Host: Neuroscience Research Institute

About the event:

It is now well recognized that during progression of a number of neurodegenerative disease such as Alzheimer’s disease, Parkinson’s disease, and prion diseases there is an innate immune response in the brain. This innate immune response is characterised by an increase in the density and activation of the microglia, as seen by the alterations in their morphology and the upregulation or de novo synthesis of macrophage antigens.

We have shown that systemic inflammation can have a profound impact on the phenotype of these microglia that appear to be ‘primed’ by the ongoing neurodegeneration. Systemic inflammation switches them from an anti-inflammatory to a pro-inflammatory phenotype with exacerbation of symptoms and an increased rate of progression of disease. Understanding how systemic co-morbidities contribute to progression of chronic neurodegenerative disease offers a route to slowing disease progression and improving the quality of life of those with neurodegenerative disease.

The seminar will be followed by a drinks reception

Registration:

Can you please register to attend, it will help with the catering.

Speaker

Prof V. Hugh Perry

Role: Centre for Biological Sciences

Organisation: University of Southampton

Travel and Contact Information

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Michael Smith Lecture Theatre
Michael Smith Building
Manchester

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Nicola Lawton

+44(0)61 275 1361

nri@manchester.ac.uk

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