Microglia priming in neurodegenerative disease |The impact of systemic inflammation
|Dates:||5 March 2014|
|Times:||16:00 - 17:00|
|What is it:||Seminar|
|Organiser:||Neuroscience Research Institute|
|Who is it for:||Current University students, University staff|
|Speaker:||Prof V. Hugh Perry|
Host: Neuroscience Research Institute
About the event:
It is now well recognized that during progression of a number of neurodegenerative disease such as Alzheimer’s disease, Parkinson’s disease, and prion diseases there is an innate immune response in the brain. This innate immune response is characterised by an increase in the density and activation of the microglia, as seen by the alterations in their morphology and the upregulation or de novo synthesis of macrophage antigens.
We have shown that systemic inflammation can have a profound impact on the phenotype of these microglia that appear to be ‘primed’ by the ongoing neurodegeneration. Systemic inflammation switches them from an anti-inflammatory to a pro-inflammatory phenotype with exacerbation of symptoms and an increased rate of progression of disease. Understanding how systemic co-morbidities contribute to progression of chronic neurodegenerative disease offers a route to slowing disease progression and improving the quality of life of those with neurodegenerative disease.
The seminar will be followed by a drinks reception
Can you please register to attend, it will help with the catering.
Prof V. Hugh Perry
Role: Centre for Biological Sciences
Organisation: University of Southampton
Travel and Contact Information
Michael Smith Lecture Theatre
Michael Smith Building