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BEGIN:VEVENT
DTSTAMP:20251208T102953Z
DTSTART:20251215T140000Z
DTEND:20251215T150000Z
SUMMARY:Freya Bull -- Blood and urine: mathematical modelling for health 
 [IN PERSON]
UID:{http://www.columbasystems.com/customers/uom/gpp/eventid/}h18c-mid5pj
 gn-gtyb33
DESCRIPTION:Join us for this seminar by Freya Bull (UCL) as part of the M
 aths in the Life Sciences seminar series (and the online North West Semi
 nar Series in Mathematical Biology and Data Sciences in collaboration wi
 th Liverpool Universities). \n\nTitle: Blood and urine: mathematical mod
 elling for health\n\nAbstract: The richness of life gives rise to many i
 nteresting physical and mathematical problems. I will talk about two of 
 them: multi-scale modelling of blood rheology in sickle cell disease\, a
 nd predicting the incidence of (urinary) catheter-associated bacteriuria
 .\n\nSickle cell disease (SCD) is a haematological disorder\, caused by 
 a genetic mutation\, in which mutant haemoglobin molecules can polymeris
 e under low-oxygen conditions\, altering the biophysical properties of t
 he red blood cells. These cell-level differences then result in changes 
 in the whole-blood rheology -- and those rheological properties are in t
 urn linked to the pathophysiology of SCD.  I use mathematical modelling 
 and numerical simulation to develop descriptions of cell-cell interactio
 ns within blood flow\, and validate these against experimental data.\n\n
 Urinary catheters are prone to colonisation by bacteria. When this leads
  to symptoms such as fever\, pain\, or inflammation\, it is known as cat
 heter associated urinary tract infection (CAUTI). CAUTI constitute up to
  40% of hospital acquired infections\, and the potential of novel materi
 als and coatings to reduce the incidence of CAUTI has attracted much att
 ention\; however none of these design changes have been found to be effe
 ctive\, with patient studies finding mixed or limited effects. Here we a
 pply a simple biophysical model for bacterial colonisation of urinary ca
 theters to predict the incidence of bacteriuria (the presence of bacteri
 a in the urine) in a clinical trial of antimicrobial catheter coatings -
 - the CATHETER trial.\n\nThe talk will be also be streamed via Teams\, p
 lease contact carl.whitfield@manchester.ac.uk or igor.chernyavsky@manche
 ster.ac.uk for the zoom link\, or sign up to the mailing list.\n\nTo sub
 scribe to the mailing list for this event series\, please send an e-mail
  with the phrase “subscribe math-lifesci-seminar” in the message body to
  listserv@listserv.manchester.ac.uk
STATUS:TENTATIVE
TRANSP:TRANSPARENT
CLASS:PUBLIC
LOCATION:1.009\, Roscoe Building\, Manchester
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