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BEGIN:VEVENT
DTSTAMP:20220321T101933Z
DTSTART:20220404T130000Z
DTEND:20220404T140000Z
SUMMARY:Chay Paterson -- Network models of carcinogenesis in colorectal a
 denocarcinoma and vestibular schwannoma
UID:{http://www.columbasystems.com/customers/uom/gpp/eventid/}h190-kzshdn
 0j-yhbuta
DESCRIPTION:(via Zoom)\nJoin us for this seminar by Chay Paterson (Manche
 ster) as part of the North West Seminar Series in Mathematical Biology a
 nd Data Sciences. Details of the full series can be found here https://w
 ww.cms.livjm.ac.uk/APMSeminar/\n\nThe talk will be hosted in Simon Build
 ing room 4.05 and via zoom\, please contact carl.whitfield@manchester.ac
 .uk or igor.chernyavsky@manchester.ac.uk for the zoom link\, or sign up 
 to the mailing list.\n\nAbstract: Multi-stage mathematical models have c
 ontributed a great deal to our understanding of cancer\, from Armitage a
 nd Doll's original work in the 1950s\, to Knudson's studies of retinobla
 stoma in the 1970s. We extend these models from linear paths to networks
  with multiple mutational pathways: somatic evolution is understood as a
  stochastic process on a directed graph\, with edges representing specif
 ic mechanisms. This approach links population incidence\, genomic data\,
  and molecular mechanisms. \n\nWhile originally developed for colorectal
  adenocarcinoma\, when applied to vestibular schwannoma\, our approach e
 nables new estimates of mutation rates in Schwann precursor cells. We al
 so try to constrain what events may trigger the extremely rare process o
 f malignant transformation of vestibular schwannoma. I make the case tha
 t this class of tumours represents an exciting opportunity to study tumo
 ur initiation and malignant transformation "in slow motion" and high res
 olution\, with evolutionary models on networks providing us with powerfu
 l analytic tools.\n\nTo subscribe to the mailing list for this event ser
 ies\, please send an e-mail with the phrase “subscribe math-lifesci-semi
 nar” in the message body to listserv@listserv.manchester.ac.uk
STATUS:TENTATIVE
TRANSP:TRANSPARENT
CLASS:PUBLIC
LOCATION:4.05 (and via zoom)\, Simon Building\, Manchester
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