Centre for Primary Care Seminar: Dr Jean Strelitz – 'Changes in weight and behaviors after diagnosis of type 2 diabetes and 10-year incidence of cardiovascular disease and mortality'
|Dates:||16 April 2019|
|Times:||13:30 - 14:30|
|What is it:||Seminar|
|Organiser:||Faculty of Biology, Medicine and Health|
|Who is it for:||University staff, Current University students|
|Speaker:||Dr Jean Strelitz|
Background: Evidence of the impact of weight loss and healthy behaviour changes on the incidence of cardiovascular disease (CVD) events among adults with diabetes is sparse and conflicting. We assessed changes in weight and behaviours following diabetes diagnosis for people who did not receive behavioural treatment and estimated associations with 10-year incidence of CVD and mortality.
Methods: Among 852 adults with screen-detected diabetes in the population-based ADDITION-Cambridge study, we estimated hazard ratios (HR) for changes in weight, diet, physical activity, and alcohol consumption in the year following diabetes diagnosis and 10-year incidence of CVD (n=116) and all-cause mortality (n=127). We estimated associations with CVD risk factors using linear regression.
Results: Loss of >=5% body weight in the year following diabetes diagnosis was associated with improvements in HbA1c and blood lipids and a lower hazard of CVD at 10 years vs. maintaining weight (HR: 0.52, 95% confidence interval: 0.32, 0.86). Those who decreased alcohol intake by >=2 units/week or decreased calorie intake by >=300 kcal/day had lower hazard of CVD and all-cause mortality, respectively, compared to participants who maintained their alcohol intake and calorie intake.
Conclusions: Among adults with screen-detected diabetes, weight loss >=5% of body weight and moderate behaviour changes during the year after diabetes diagnosis were associated with lower hazard of CVD events. Patients, practitioners and policy-makers may consider focusing greater attention to establishing behavioural and weight loss targets following diabetes diagnosis, which may be achievable outside of specialist-led treatment programs.
Dr Jean Strelitz
Role: Postdoctoral Fellow
Organisation: University of Cambridge MRC Epidemiology Unit
Travel and Contact Information
Seminar Room, Fifth Floor