BEGIN:VCALENDAR
PRODID:-//Columba Systems Ltd//NONSGML CPNG/SpringViewer/ICal Output/3.3-
 M3//EN
VERSION:2.0
CALSCALE:GREGORIAN
METHOD:PUBLISH
BEGIN:VEVENT
DTSTAMP:20150605T115822Z
DTSTART:20150630T120000Z
DTEND:20150630T130000Z
SUMMARY:The glomerular matrisome in Alport syndrome / Novel concepts of m
 icrotubule regulation during neuronal growth\, maintenance and degenerat
 ion
UID:{http://www.columbasystems.com/customers/uom/gpp/eventid/}h6u-iajk3j6
 o-22yliu
DESCRIPTION:The glomerular matrisome in Alport syndrome:\n\nThe glomerula
 r capillary wall is a highly sophisticated filtration barrier. Cell-matr
 ix adhesion is essential for barrier integrity and ultimately for renal 
 survival. Alport Syndrome results in renal failure and is caused by gene
 tic defects in COL4A3\, COL4A4 or COL4A5\, but despite this knowledge th
 ere are currently no targeted therapies. We used proteomic and ultrastru
 ctural analysis to define the molecular landscape of cell-matrix adhesio
 n in the glomerulus of Col4a3-/- (Alport) mice.\n\n\nNovel concepts of m
 icrotubule regulation during neuronal growth\, maintenance and degenerat
 ion:\n\nAxons are very long\, delicate structures that need to be mainta
 ined over decades. Parallel bundles of microtubules (MTs) form their str
 uctural backbones and transport highways. We study mechanisms of the MT 
 regulating machinery in axons using versatile combinatorial genetics of 
 Drosophila.\nSpectraplakins guide polymerising microtubules along cortic
 al F-actin\, thereby laying axonal MTs out into parallel bundles. Here\,
  we propose two novel mechanisms of local MT homeostasis: 1) A membrane-
 anchored cortical collapse factor serves as a check point by eliminating
  "off track" MTs that have escaped the guidance mechanism. 2) Axonal act
 in sustains the polymerisation of off-track MTs\, thus counterbalancing 
 MT collapse factor functions. Using super-resolution microscopy in combi
 nation with genetics\, we have started to dissect actin network properti
 es required for this function in neurons.\nOur model of local MT homeost
 asis is novel and provides unprecedented understanding of mechanisms und
 erlying axon longevity and degeneration.
STATUS:TENTATIVE
TRANSP:TRANSPARENT
CLASS:PUBLIC
LOCATION:Michael Smith Lecture Theatre\, Michael Smith Building\, Manches
 ter
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