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PRODID:-//Columba Systems Ltd//NONSGML CPNG/SpringViewer/ICal Output/3.3-
 M3//EN
VERSION:2.0
CALSCALE:GREGORIAN
METHOD:PUBLISH
BEGIN:VEVENT
DTSTAMP:20160121T095441Z
DTSTART:20160318T140000Z
DTEND:20160318T150000Z
SUMMARY:Regenerating CNS myelin – from mechanisms to medicines
UID:{http://www.columbasystems.com/customers/uom/gpp/eventid/}i26-ieldyal
 b-ohfsi4
DESCRIPTION:Part of the Manchester Tissue Regeneration & Stem Cell Networ
 k Seminar Series. Sponsored by New England Biolabs (NEB)\n\nRemyelinatio
 n\, the process by which new myelin sheaths are restored to demyelinated
  axons\, represents one of the most compelling examples of adult multipo
 tent stem cells contributing to regeneration of the injured CNS. This pr
 ocess can occur with remarkable efficiency in multiple sclerosis (MS)\, 
 and in experimental models\, revealing an impressive ability of the adul
 t CNS to repair itself. However\, the inconsistency of remyelination in 
 MS\, and the loss of axonal integrity that results from its failure\, ma
 kes enhancement of remyelination an important therapeutic objective. The
 re is now compelling evidence that ageing is the major contributor to th
 e declining efficiency of remyelination and that this is largely due to 
 a failure of stem cell differentiation. This talk will review recent stu
 dies we have undertaken aimed at obtaining a detailed understanding of t
 he mechanisms of regulating differentiation during remyelination and hen
 ce identifying novel therapeutic targets.
STATUS:TENTATIVE
TRANSP:TRANSPARENT
CLASS:PUBLIC
LOCATION:Michael Smith Lecture Theatre\, Michael Smith Building\, Manches
 ter
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