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PRODID:-//Columba Systems Ltd//NONSGML CPNG/SpringViewer/ICal Output/3.3-
 M3//EN
VERSION:2.0
CALSCALE:GREGORIAN
METHOD:PUBLISH
BEGIN:VEVENT
DTSTAMP:20140403T081825Z
DTSTART:20140411T130000Z
DTEND:20140411T140000Z
SUMMARY:Generating and regenerating blood and the heart
UID:{http://www.columbasystems.com/customers/uom/gpp/eventid/}i2i-hp2pze1
 6-d36jj6
DESCRIPTION:This seminar is part of the Manchester Tissue Regeneration & 
 Stem Cell Network seminar series.                                       
                                                                         
                                                                A key pro
 perty of stem cells is the ability to divide without\, or with restricte
 d\, differentiation.  To gain insight into the mechanisms by which diffe
 rentiation is controlled in blood (HSCs)\, and potential cardiovascular\
 , stem cells\, we are looking for clues as to how this property is progr
 ammed into the nuclei of these cells during development.  We have identi
 fied the locations of HSC precursors\, and many of the signals that prog
 ramme them up to and including their emergence from the floor of the dor
 sal aorta.  We are beginning to link the signals to specific transcripti
 on factors and miRNAs\, and to determine the cross-talk between them as 
 they build stable regulatory networks.  An emerging candidate mechanism 
 for restricting differentiation is cross-antagonism between competing li
 neage-affiliated transcription factors.  We have identified such a mecha
 nism as early as the branching between cardiac and blood/endothelial pro
 genitors within the lateral plate mesoderm\, and we have identified the 
 signal that drives the decision.  Extending the domain of influence of t
 his signal may have been involved in the enlargement of the heart during
  evolution.  Furthermore\, the precursors with endothelial as well as ca
 rdiac potential may provide a handle on progenitors of interest to regen
 eration of the adult heart.
STATUS:TENTATIVE
TRANSP:TRANSPARENT
CLASS:PUBLIC
LOCATION:Lecture Theatre\, Michael Smith Building\, Manchester
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