BEGIN:VCALENDAR
PRODID:-//Columba Systems Ltd//NONSGML CPNG/SpringViewer/ICal Output/3.3-
 M3//EN
VERSION:2.0
CALSCALE:GREGORIAN
METHOD:PUBLISH
BEGIN:VEVENT
DTSTAMP:20140605T102017Z
DTSTART:20140611T120000Z
DTEND:20140611T130000Z
SUMMARY:A neural circuit model of the oculomotor integrator: theory for o
 ptogenetic dissection
UID:{http://www.columbasystems.com/customers/uom/gpp/eventid/}j1ag-hw1wxu
 jx-xdu8yi
DESCRIPTION:The oculomotor integrator (OI) in the hindbrain transforms in
 coming horizontal eye movement commands into position signals to maintai
 n stable eye fixations after saccades. Previous electrophysiological and
  pharmacological investigations of the system have shown that neurons in
  the OI have firing rates that can persist at a continuum of levels\, wi
 th each level corresponding to a particular fixation. These findings hav
 e led to the hypothesis that the OI has a continuum of stable stationary
  states\, giving rise to a continuous attractor network. In this work\, 
 we will show that several models can account for previous results\, yet 
 differ in their dynamical behavior after instantaneous perturbations of 
 the OI. To further constrain the models\, we performed optogenetic pertu
 rbations in the OI of zebrafish. The resulting instantaneous eye movemen
 ts suggest that the dynamics of the OI are organized around a central at
 tractor state. These results pose new constraints on the circuit connect
 ivity of the system\, and highlight the potential of the combination of 
 optogenetics with theoretical models to unveil neural circuit dynamics. 
 (Joint work with Aristides Arrenberg\, Bastian Hablitzel\, Herwig Baier 
 and Christian Machens)
STATUS:TENTATIVE
TRANSP:TRANSPARENT
CLASS:PUBLIC
LOCATION:4.005\, AV Hill Building\, Manchester
END:VEVENT
END:VCALENDAR