BEGIN:VCALENDAR
PRODID:-//Columba Systems Ltd//NONSGML CPNG/SpringViewer/ICal Output/3.3-
 M3//EN
VERSION:2.0
CALSCALE:GREGORIAN
METHOD:PUBLISH
BEGIN:VEVENT
DTSTAMP:20250122T115822Z
DTSTART:20250205T140000Z
DTEND:20250205T145000Z
SUMMARY:Statistics Seminar - A taxonomy of designs for randomised optimis
 ation trials of therapist-led interventions: A systematic overview of me
 thods 
UID:{http://www.columbasystems.com/customers/uom/gpp/eventid/}j1gd-m67tvn
 ad-el91mg
DESCRIPTION:Dr. Rebecca Walwyn\nUniversity of Leeds\n\nAbstract\n\nBackgr
 ound: Therapist-led interventions such as psychotherapy are complex\, de
 livered by therapists to individuals\, and commonly evaluated in randomi
 sed trials. How the randomisation incorporates the therapist is pivotal 
 to the design\, yet little is known about how this is done in practice.\
 nAim: To introduce a taxonomy of designs used in randomised trials and t
 o summarise the practical constraints reported.\nMethods: Systematic met
 hods overview of the designs reported and discussed in randomised trials
  in general medical journals and specialist journals from 1980 to 2022. 
 Searches in MEDLINE\, EMBASE\, PsycInfo were conducted in November 2022.
  Protocol or main results papers that evaluated an intervention delivere
 d at least in part by a therapist to patients in a randomised trial were
  eligible\, with no restriction on therapist profession or patient condi
 tion.\nResults: 821 papers were screened\, with 474 meeting eligibility 
 criteria\, relating to 459 trials. Of these\, 91 (20%) evaluated a group
 -based therapy. Of the 368 that did not\, 58 (16%) included therapists a
 s a stratification factor\, a treatment factor\, or a unit in the random
 isation. We will set out 10 of the possible trial designs\, broadly base
 d on these 58 historical examples\, using diagrams to clearly describe t
 he randomisation. Common constraints on the trial design included therap
 ist availability at the point of randomisation\, therapist turnover\, an
 d variability in caseloads.\nDiscussion: A wide range of trial designs a
 re used in practice. The therapist is included as a factor in the random
 isation in a sizeable minority. Guidance is needed\, addressing common p
 ractical constraints.
STATUS:TENTATIVE
TRANSP:TRANSPARENT
CLASS:PUBLIC
LOCATION:Frank Adams 2\, Alan Turing Building\, Manchester
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