Special seminar: Super-resolution microscopy revolutionizes kidney research, diagnostics and drug development.
| Dates: | 24 July 2023 |
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| Times: | 12:00 - 13:00 |
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| What is it: | Seminar |
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| Organiser: | Faculty of Biology, Medicine and Health |
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| Who is it for: | University staff, Current University students |
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| Speaker: | Nicole Endlich |
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Super-resolution microscopy is a highly powerful tool in biomedical research, offering high resolution and imaging capabilities beyond the diffraction limit of traditional light microscopy. There are several reasons why super-resolution microscopy holds significant promise for kidney research, to personalize nephrology and accelerate drug development.
Super-resolution microscopy techniques, such as structured illumination microscopy (SIM), provide a breakthrough in visualizing cellular and subcellular structures with exceptional detail. By overcoming the limitations of conventional microscopy, super-resolution techniques enable researchers to study the ultrastructure of renal cells, such as podocytes, mesangial epithelial cells, and glomerular basement membrane with precision and often in a quantitative fashion. This enhanced resolution allows e.g. the visualization of tiny podocyte foot processes, the filtration membrane as well as details of the GBM in an unbiased and quantitative way. In contrast to the electron microscopy, SIM allows the analysis of double and triple stainings of standard histological slides, fast, unbiased and quantitative.
As super-resolution microscopy continues to advance, it holds great promise for future breakthroughs in kidney research, ultimately leading to improved diagnostics, therapies, and treatments for renal disorders, but also for the analysis of a high number of animal models such as mice, rat, pigs and non human primates as well as organoids.
Speaker
Nicole Endlich
Role: Professor
Organisation: University of Medicine Greifswald
Travel and Contact Information
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1.006
AV Hill Building
Manchester
