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BEGIN:VEVENT
DTSTAMP:20210301T092100Z
DTSTART:20210303T130000Z
DTEND:20210303T140000Z
SUMMARY:Florien Pein - Model-Free Idealisation of Patchclamp Recordings
UID:{http://www.columbasystems.com/customers/uom/gpp/eventid/}l1l9-klqdh0
 f9-l9q65k
DESCRIPTION:(via Zoom)\nJoin us for this seminar by Florien Pein (Cambrid
 ge) as part of the North West Seminar Series in Mathematical Biology and
  Data Sciences. Details of the full series can be found here https://www
 .cms.livjm.ac.uk/APMSeminar/\n\nPlease contact carl.whitfield@manchester
 .ac.uk or I.Siekmann@ljmu.ac.uk for the zoom link\, or sign up to the ma
 iling list.\n\nAbstract: The voltage patchclamp technique is a fundament
 al tool for the quantitative analysis of electrophysiological processes 
 of transmembrane proteins\, in particular of ion channels. Analysis of p
 atchclamp recordings is often a challenging issue. In this talk we prese
 nt a very general non-parametric model for such recordings. Based on thi
 s model we provide fully automatic model-free idealisation methods or in
  statistical words non-parametric estimation methods. Patchclamp recordi
 ngs are typically lowpass filtered to suppress high-frequent noise compo
 nents. Hence\, a major point of our approaches is to take the filtering 
 into account explicitly.\nIn a second step\, we show how idealisations a
 llowing us to obtain biochemical relevant information about the underlyi
 ng gating dynamics. Finally\, we discuss advantages and disadvantages of
  model-free approaches in comparison to hidden Markov model approaches a
 nd explain how they complement each other. Our methods are available as 
 an R-package and as a graphical user interface.\n\nTo subscribe to the m
 ailing list for this event series\, please send an e-mail with the phras
 e “subscribe math-lifesci-seminar” in the message body to listserv@lists
 erv.manchester.ac.uk
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