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PRODID:-//Columba Systems Ltd//NONSGML CPNG/SpringViewer/ICal Output/3.3-
 M3//EN
VERSION:2.0
CALSCALE:GREGORIAN
METHOD:PUBLISH
BEGIN:VEVENT
DTSTAMP:20150826T085506Z
DTSTART:20150904T140000Z
DTEND:20150904T150000Z
SUMMARY:Celebrating FLS Research Success: mRNA selection for translation:
  new perspectives on the cytosolic site of translation and the machinery
  involved
UID:{http://www.columbasystems.com/customers/uom/gpp/eventid/}l7-idsjotuk
 -eybav5
DESCRIPTION:The next seminar in the ‘Celebrating Research Success in FLS’
  series will be given by Dr Mark Ashe\, who is a member of the Computati
 onal and Evolutionary Biology (CEB) Research Theme (sub theme: Functiona
 l Genomics and System Biology). The seminar will take place on Friday 4 
 September\, 3-4pm\, in Michael Smith Lecture Theatre. The seminar is sch
 eduled to take place just prior to FLS Happy Hour to allow discussions a
 nd networking to continue after the actual presentation.\n\n\nMark’s pre
 sentation will be entitled ‘mRNA selection for translation: new perspect
 ives on the cytosolic site of translation and the machinery involved’ an
 d will focus on two of his publications:\n* Costello J\, Castelli LM\, R
 owe W\, Kershaw CJ\, Talavera D\, Mohammad-Qureshi SS\, Sims PF\, Grant 
 CM\, Pavitt GD\, Hubbard SJ\, Ashe MP. 2015. Global mRNA selection mecha
 nisms for translation initiation. Genome Biol. 16: 10.\n* Lui J\, Castel
 li LM\, Pizzinga M\, Simpson CE\, Hoyle NP\, Bailey KL\, Campbell SG\, A
 she MP. 2014. Granules harboring translationally active mRNAs provide a 
 platform for P-body formation following stress. Cell Rep. 9: 944-54.\n\n
 \n\nAbstract\nTwo recent studies from the lab have challenged current pe
 rceptions as to how individual mRNAs are translated. Firstly\, we have f
 ound that some heavily translated mRNAs that encode cytosolic proteins a
 re localised to specific foci while being translated\, and have started 
 to explore potential reasons for this localised translation. Secondly\, 
 the machinery responsible for selecting mRNAs for translation interacts 
 poorly with these localised mRNAs even though hey are heavily translated
 . These results have highlighted a potential role for localised mRNA tra
 nslation in the co-regulation or folding of nascent proteins in the same
  complex or pathway\, and in the inheritance of key mRNAs during the cel
 l cycle.
STATUS:TENTATIVE
TRANSP:TRANSPARENT
CLASS:PUBLIC
LOCATION:Michael Smith Lecture Theatre
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