BEGIN:VCALENDAR
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VERSION:2.0
CALSCALE:GREGORIAN
METHOD:PUBLISH
BEGIN:VEVENT
DTSTAMP:20140307T100649Z
DTSTART:20140311T153000Z
DTEND:20140311T170000Z
SUMMARY:Using genome engineering to reinvestigate the range of Wnt signal
 ling
UID:{http://www.columbasystems.com/customers/uom/gpp/eventid/}l92-hqdsu7i
 g-c6sxhy
DESCRIPTION:This seminar is part of the Fly Club Seminar Series.\n\nJean-
 Paul Vincent\nhttp://www.nimr.mrc.ac.uk/research/jean-paul-vincent/\nNat
 ional Institute for Medical Research\n\nThroughout his career\, Jean Pau
 l has made important contributions to the field of Developmental Biology
 \, in particular the topics of signalling and pattern formation. His lat
 est publication\, just published in Nature (http://www.nature.com/nature
 /journal/v505/n7482/full/nature12879.html)\, has stirred up an important
  debate in the field by challenging the generally accepted notion that m
 orphogens\, in particular Wnts\, need to spread out from an organising c
 entre to control growth and patterning  (see also: http://amapress.gen.c
 am.ac.uk/?p=1191). \n\nAbstract:\n \nA small number of signalling molecu
 les orchestrate growth and cell fate decisions during development. We us
 e techniques of genome engineering and cell biology to investigate the m
 echanisms that control the production\, spread and activity of one signa
 l\, Wingless (the main Drosophila member of the Wnt family). We recently
  found that flies develop and grow ‘Using genome engineering to re-inves
 tigate the range of Wnt signalling' almost normally following replacemen
 t of the endogenous wingless coding region with a cDNA encoding a membra
 ne-tethered form.  This is surprising because Wingless has been thought 
 as an archetypical morphogen\, particularly in wing progenitors. Two pro
 cesses contribute to obviating the need for Wingless to spread. First\, 
 the target tissue produces its own supply of Wingless during the early p
 eriod of growth and patterning. Later\, after local expression terminate
 s\, the expression of key Wingless target genes persists by a mechanism 
 akin to cellular memory. We are currently determining the molecular basi
 s of cellular memory. Although Wingless release is not essential\, it do
 es occur. I will describe evidence that Wingless release contributes to 
 growth in both an organ-autonomous and organism-wide manner. \n \nHosted
  by the Fly Club committee\n \nAll Welcome
STATUS:TENTATIVE
TRANSP:TRANSPARENT
CLASS:PUBLIC
LOCATION:Lecture Theatre\, Michael Smith Building\, Manchester
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