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PRODID:-//Columba Systems Ltd//NONSGML CPNG/SpringViewer/ICal Output/3.3-
 M3//EN
VERSION:2.0
CALSCALE:GREGORIAN
METHOD:PUBLISH
BEGIN:VEVENT
DTSTAMP:20190207T072500Z
DTSTART:20190307T130000Z
DTEND:20190307T140000Z
SUMMARY:Targeting the Hyaluronan-Based Extracellular Matrix to Reverse Ne
 urodegenerative Disease
UID:{http://www.columbasystems.com/customers/uom/gpp/eventid/}lvd-jruardx
 h-9k5woe
DESCRIPTION:The glycosaminoglycan hyaluronan (HA) is elevated in the cent
 ral nervous system (CNS) following a number of insults including neurode
 generative diseases. We have found that this HA is digested into fragmen
 ts in damaged CNS tissues through the actions of hyaluronidases.  These 
 fragments signal in neural progenitor cell populations through a non-can
 onical toll-like receptor 4 pathway that alters both neuronal and glial 
 cell gene transcription. Increased hyaluronidase activity in the hippoca
 mpus leads to alterations in adult neurogenesis and cognitive function\,
  while in white matter\, hyaluronidase activity blocks the maturation of
  progenitors involved in nervous system repair. We recently identified n
 ovel hyaluronidase inhibitors and demonstrated that these agents can pro
 mote nervous system repair in models of human neurodegenerative diseases
 . These agents are now being tested in pre-clinical trials.
STATUS:TENTATIVE
TRANSP:TRANSPARENT
CLASS:PUBLIC
LOCATION:Lecture Theatre\, Michael Smith Building\, Manchester
END:VEVENT
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