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METHOD:PUBLISH
BEGIN:VEVENT
DTSTAMP:20240418T142745Z
DTSTART:20240423T120000Z
DTEND:20240423T130000Z
SUMMARY:Advances in Biosciences Seminar - Konstantinos Beis\, Imperial Co
 llege London. Title: The peculiarities of transporters
UID:{http://www.columbasystems.com/customers/uom/gpp/eventid/}m32w-lu2u22
 n2-bkez16
DESCRIPTION:Abtract: Transporters are found in all forms of life\, and th
 ey are associated with the import of nutrients or the export of antibiot
 ics and xenobiotics causing multidrug resistance. Transporters can be cl
 assified either as ABC transporters (ATP-driven) or secondary active tra
 nsporters (proton/sodium driven). I will present recent work from the la
 b on two transporters that display certain peculiarities compared to the
  accepted working models in the field. The antibacterial peptide transpo
 rter SbmA is involved in peptide transport in gram-negative bacteria\; t
 his is a rather unique transporter that has an ABC transporter like fold
  (we call it SbmA-like peptide transporter fold (SLiPT))\, but it is ene
 rgised by the proton gradient rather than ATP. Mechanistically\, SbmA be
 haves like an ABC transporter from our cryo-EM structures and functional
  data. The second oddity is the multidrug resistance protein 2 (MRP2)\; 
 MRP2 exports bilirubin and it is associated with chemotherapy resistance
  in the liver canalicular membrane. The activity and function of MRP2 is
  regulated by phosphorylation and drug-drug interactions. Our cryo-EM st
 ructures\, phosphoproteomic analysis and transport data in human hepatoc
 yte-like cells have allowed us to gain mechanistic insights on this rath
 er peculiar regulation by both endogenous kinases and drugs.
STATUS:TENTATIVE
TRANSP:TRANSPARENT
CLASS:PUBLIC
LOCATION:Michael Smith Lecture Theatre\, Michael Smith Building\, Manches
 ter
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