Structural biology of the laminin network
| Dates: | 28 January 2014 |
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| Times: | 13:00 - 14:00 |
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| What is it: | Seminar |
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| Organiser: | Faculty of Life Sciences |
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| Who is it for: | University staff |
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| Speaker: | Erhard Hohenester |
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This seminar is part of the Tissue Systems seminar series. Laminins are a defining component of all basement membranes and essential for multicellular life. How laminins polymerise into cell-associated networks and how they mediate cell adhesion remains incompletely understood. My research is tackling these questions by crystallographic structure determination of selected laminin fragments and by structure-guided biochemical experiments. In my seminar, I will briefly review the current understanding of cell adhesion to the laminin G domain and then discuss our recent advances in defining the molecular mechanism of laminin polymerisation. Although I will show atomic structures, I aim to make my presentation accessible to anyone with an interest in protein function and extracellular matrix biology.
Speaker
Erhard Hohenester
Organisation: Imperial College London
Travel and Contact Information
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Lecture Theatre
Michael Smith Building
Manchester
