DCS Next Generation Seminar: Dr Kasper Rasmussen, University of Dundee: “Targeting mitochondrial nucleotide metabolism in cancer” 30 January 23
|Dates:||30 January 2023|
|Times:||16:00 - 17:00|
|What is it:||Seminar|
|Organiser:||Faculty of Biology, Medicine and Health|
|Who is it for:||University staff, External researchers, Adults, Alumni, Current University students|
|Speaker:||Dr Kasper Rasmussen ,|
You are invited to join the Division of Cancer Sciences in welcoming Dr Kasper Rasmussen, from the Division of Molecular, Cellular and Developmental Biology (MCDB) at University of Dundee, for his upcoming talk.
DNA methylation in gene regulation and hematological malignancies
The epigenetic mark of DNA methylation is established by DNMT (DNA methyltransferase) enzymes and has been shown to correlate with transcriptional states and influence cell identity and tumorigenesis in mammalian cells. The discovery that TET (Ten-Eleven-Translocation) enzymes can oxidise methylated bases in the genome and produce 5-hydromethylcytosine (5hmC), 5-formylcytosine (5fC), 5-carboxycytosine (5caC) and mediate passive and active DNA demethylation has opened a new avenue to understand how DNA methylation dynamics affect transcriptional programs and development of diseases (Rasmussen and Helin, Genes Dev 2016). Mutations in TET2 and DNMT3A are frequently found in the aging population (a condition known as age-related “clonal hematopoiesis” that predispose individuals to atherosclerosis, venous thrombosis and heart failure as well as in a wide range of overt blood diseases. However, the events that cause hematopoietic stem cell to expand and transform following the occurrence of these mutations remain unclear. Understanding the basic mechanisms that govern preleukaemic stem cells can therefore aid in the identification of ways to prevent disease and promote healthy aging. In 2019, I was awarded a Cancer Research UK Career Development fellowship and have started a research group at University of Dundee to explore aspects of aberrant DNA methylation in blood diseases. In this seminar, I will present our recent work on TET2 function in hematopoiesis as well as our efforts to develop a tractable model system for human clonal hematopoiesis.
Please contact SMS-PS-Team1@manchester.ac.uk for further information, to arrange a meeting with Dr Kasper Rasmussen, or to forward questions in advance.
Dr Kasper Rasmussen
Organisation: University of Dundee
Travel and Contact Information
Lecture Theatre & Zoom
Oglesby Cancer Research Building
555 Wilmslow Road