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METHOD:PUBLISH
BEGIN:VEVENT
DTSTAMP:20190912T125604Z
DTSTART:20190923T130000Z
DTEND:20190923T135000Z
SUMMARY:Adriana Dawes - Modeling cell fate specification in organogenesis
 
UID:{http://www.columbasystems.com/customers/uom/gpp/eventid/}ni3-k0ghz15
 e-sh73nz
DESCRIPTION:(Room 3.44b Simon Building)\nJoin us for this seminar by Adri
 ana Dawes (Ohio State) as part of the Mathematics in the Life Sciences S
 eries.\n\nAbstract:\nNematode worms of the genus Caenorhabditis rely on 
 an egg laying structure\, called the vulva\, to properly expel embryos f
 rom the adult body. Development of the vulva involves six vulval precurs
 or cells (VPCs) which can adopt one of three possible cell fates. The ph
 ysical structure and signaling pathways involved in vulval development a
 re highly conserved across nematode worms\, although recent data shows d
 ifferential responses in cell fate to partial pathway disruption between
  two species\, C. elegans and C. briggsae. In order to investigate the p
 athway components that may be responsible for these species-specific dif
 ferences\, we developed a biologically based mathematical model of the m
 ain signaling networks (EGF/Ras\, Notch and Wnt) responsible for VPC cel
 l fate specification. With this model\, we have identified key component
 s that account for the observed species-specific responses. In particula
 r\, we find that C. elegans-like parameter sets are more sensitive to di
 sruptions in the EGF/Ras signaling pathway than C. briggsae-like paramet
 er sets\, and that differences in the spatial distribution of Wnt signal
 ing may be responsible for the C. briggsae robustness. Taken together\, 
 the data analysis and visualization in this project have allowed us to i
 dentify modifications in the underlying interaction network that may giv
 e rise to the experimentally observed phenotypic variability.\n\nTo subs
 cribe to the mailing list for this event series\, please send an e-mail 
 with the phrase “subscribe math-lifesci-seminar” in the message body to 
 listserv@listserv.manchester.ac.uk\n
STATUS:TENTATIVE
TRANSP:TRANSPARENT
CLASS:PUBLIC
LOCATION:3.44b\, Simon Building\, Manchester
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