The extracellular matrix fine-tunes the innate immune response to infection
| Starts: | 10:30 5 Feb 2015 |
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| Ends: | 11:30 5 Feb 2015 |
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| What is it: | Seminar |
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| Organiser: | Faculty of Life Sciences |
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| Who is it for: | University staff, Current University students |
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| Speaker: | Dr Anna M. Piccinini |
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De-regulation of the host response to infection can lead to systemic inflammatory conditions such as sepsis, where tissue damage and organ failure result from excessive pro-inflammatory gene expression upon bacterial invasion. However, it remains unclear how the mechanisms that keep the immune response in check fail. Dr Piccinini will discuss a novel role for the extracellular matrix glycoprotein tenascin-C in regulating immunity triggered in response to infection. Post-transcriptional control of cytokine synthesis via induction of miR-155 by tenascin-C constitutes a unique means of fine tuning the immune response.
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1.006
AV Hill Building
Manchester
