The export of collagens from the Endoplasmic Reticulum
| Starts: | 13:00 7 Jun 2016 |
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| Ends: | 14:00 7 Jun 2016 |
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| What is it: | Seminar |
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| Organiser: | Faculty of Life Sciences |
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| Who is it for: | University staff, Current University students |
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| Speaker: | Antonio Santos |
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COPII-coated vesicles mediate export of secretory cargos from the endoplasmic reticulum (ER). However, a standard COPII-vesicle with a diameter of 60-90 nm is too small to accommodate collagens, composed of rigid triple helices of up to 400 nm in length; or pre-chylomicrons, bulky lipid particles of up to 500 nm in diameter. So how are collagens and chylomicrons packed and exported from the ER into the secretory pathway? This issue is of fundamental importance since collagens constitute approximately 25% of our dry body weight and are essential for cell-cell interactions and chylomicrons are indispensable for cholesterol homeostasis in mammals. During my talk I will first present our most recent findings on the role of TANGO1 and a TANGO1-like protein (TALI) in the export of pre-chylomicrons from the ER. Both TANGO1 and TALI are transmembrane ER-resident proteins, but only TANGO1 is required to the export of collagens from the ER. I will then show that TANGO1 directly recruits YKT6-containing ERGIC (ER Golgi Intermediate Compartment) membranes for fusion with collagen-enriched patches at the ER, leading to the formation of a mega carrier. We propose that TANGO1 mediates the formation of mega carriers for the export of bulky cargos from the ER. These are fundamentally different from standard COPII-vesicles used for the export of small cargoes.
Speaker
Antonio Santos
Organisation: Centre for Genomic Regulation, Barcelona
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Michael Smith Lecture Theatre
Michael Smith Building
Manchester
