BEGIN:VCALENDAR
PRODID:-//Columba Systems Ltd//NONSGML CPNG/SpringViewer/ICal Output/3.3-
 M3//EN
VERSION:2.0
CALSCALE:GREGORIAN
METHOD:PUBLISH
BEGIN:VEVENT
DTSTAMP:20220317T101042Z
DTSTART:20220406T100000Z
DTEND:20220406T110000Z
SUMMARY:The process and impact of ageing on the extracellular matrix
UID:{http://www.columbasystems.com/customers/uom/gpp/eventid/}o1fv-l0utbe
 c2-5u9n1b
DESCRIPTION:In mammals\, tissues are composed of both cells and an organi
 sed scaffold of proteins known as the extracellular matrix (ECM)\, which
  not only provides mechanical support and a surface for cells to attach 
 to\, but also plays an important role in controlling cell behaviour. Man
 y of the diseases which affect ageing humans involve profound changes to
  the ECM in organs like the intervertebral disc (degeneration)\, lung (e
 mphysema)\, blood vessel (atherosclerosis) and skin (fragility). In cont
 rast to the dynamic environment inside cells\, where proteins are made a
 nd recycled on a daily basis\, many ECM assemblies like collagen and ela
 stic fibres can exist for decades in human tissues. Cell ageing is relat
 ively well understood compared to ECM ageing. Events happen quickly in c
 ells which constantly monitor and repair damaged proteins and DNA. Howev
 er\, since the ECM is located outside of cells\, few mechanisms exist to
  detect and repair damage to ECM proteins. This makes long-lived ECM ass
 emblies vulnerable to the gradual accumulation of damage by long-term ex
 posure to agents such as reactive oxygen species (ROS)\, protein modifyi
 ng enzymes\, and sugars.\n\nWhilst well-developed biological analysis te
 chniques exist to identify differences in the abundance of proteins in t
 issues\, identifying ECM proteins which have accumulated damage during a
 geing remains extremely difficult. In this webinar\, Dr Michael Sherratt
  (The University of Manchester) will introduce how the ECM ages and its 
 impact on skin. Prof Danny Chan (The University of Hong Kong) will then 
 take us through how ECM remodelling in the ageing intervertebral disc ca
 n be characterised using proteomic mass spectrometry analyses. Finally D
 r Alex Eckersley (The University of Manchester) will end by presenting a
  novel proteomic analysis approach (Peptide Location Fingerprinting) for
  identifying damaged ECM across multiple tissues (skin\, lung\, artery a
 nd disc)\, alongside their potential mechanisms and consequences of agei
 ng.
STATUS:TENTATIVE
TRANSP:TRANSPARENT
CLASS:PUBLIC
END:VEVENT
END:VCALENDAR