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PRODID:-//Columba Systems Ltd//NONSGML CPNG/SpringViewer/ICal Output/3.3-
 M3//EN
VERSION:2.0
CALSCALE:GREGORIAN
METHOD:PUBLISH
BEGIN:VEVENT
DTSTAMP:20130604T095924Z
DTSTART:20130605T120000Z
DTEND:20130605T130000Z
SUMMARY:Studying Large-Scale Brain Networks: Electrical Stimulation & Neu
 ral-Event-Triggered fMRI
UID:{http://www.columbasystems.com/customers/uom/gpp/eventid/}oc-hfjrrbkn
 -unwf51
DESCRIPTION:'''Host:''' Biomedical Imaging Institute\n\n'''Speaker:''' Ni
 kos Logothetis\n\n\n'''Location:''' The event will now be taking place i
 n Lecture Theatre 4\, Stopford Building\n\n'''Registration:''' Please co
 mplete the on-line registration form: https://apps.mhs.manchester.ac.uk/
 surveys/TakeSurvey.aspx?PageNumber=1&SurveyID=86LJ8885&Preview=true\n\n'
 ''About the seminar:''' \nThe brain is "the" example of an adaptive\, co
 mplex system. It is characterized by ultra-high structural complexity an
 d massive connectivity\, both of which change and evolve in response to 
 experience. Information related to sensors and effectors is processed in
  both a parallel and a hierarchical fashion. The connectivity between di
 fferent hierarchical levels is bidirectional\, and its effectiveness is 
 continuously controlled by specific associational and neuromodulatory ce
 nters. In the study of such systems one major problem is the adequate de
 finition for an elementary operational unit (often called an "agent")\, 
 because any such module can be a complex system in its own right and may
  be recursively decomposed into other sets of units. A second difficulty
  arises from the synergistic organization of complex systems and of the 
 brain in particular. Synergy here refers to the fact that the behavior o
 f an integral\, aggregate\, whole system cannot be trivially reduced to\
 , or predicted from\, the components themselves. Localizing and comprehe
 nding the neural mechanisms underlying our cognitive capacities demands 
 the combination of multimodal methodologies\, i.e. it demands concurrent
  study of components and networks\; one way of doing this\, is to combin
 e invasive methods which afford us direct access to the brain’s electric
 al activity at the microcircuit level with global imaging technologies s
 uch as magnetic resonance imaging (MRI). In his talk\, Nikos will discus
 s two such methodologies: Direct Electrical Stimulation and fMRI (DES-fM
 RI) and Neural-Event-Triggered fMRI (NET-fMRI).\n\nDES-fMRI can be used 
 in hopes of gaining insight into the functional or effective connectivit
 y underlying DES-induced behaviors. Yet\, first findings suggest that DE
 S has an important limitation: it clearly demarcates all monosynaptic ta
 rgets of a stimulated site\, but it largely fails to reveal polysynaptic
  cortico-cortical connectivity.\n\nNET-fMRI\, on the other hand\, appear
 s to offer great potential for mapping whole-brain activity that is asso
 ciated with individual local events. In the second part of his talk\, Ni
 kos will describe the characteristic states of widespread cortical and s
 ubcortical networks that are associated with the occurrence of hippocamp
 al sharp waves and ripples\; the brief aperiodic episodes associated wit
 h memory consolidation.\n\nTo find out more about this and other BII eve
 nts\, please go to the BII Events page: http://www.bii.manchester.ac.uk/
 aboutus/Events/\n\n\n
STATUS:TENTATIVE
TRANSP:TRANSPARENT
CLASS:PUBLIC
LOCATION:Lecture Theatre 4\, Stopford Building\, Manchester
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