Life is sweet-glycomics and glycoproteomics-providing new biological insights
| Dates: | 23 January 2015 |
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| Times: | 12:00 - 13:00 |
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| What is it: | Seminar |
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| Organiser: | Faculty of Life Sciences |
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| Speaker: | Stuart Haslam |
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Glycans, in the form of polysaccharides or glycoconjugates, are the most abundant class of biomolecules. Every cell has multiple types of glycan on its surface where they play vital roles in cell-cell and cell-matrix interactions. Structural determination is essential for understanding the roles that glycans play in biological systems. Mass spectrometry (MS), with its ultra-high sensitivity and ability to analyse complex mixtures of glycans, is the most powerful tool currently available for glycan structure analysis. Our laboratory is engaged in numerous world-wide collaborations in which we exploit high sensitivity mass spectrometric methodologies for the structural characterization of glycans found in a diverse range of biological material. This presentation will review MS strategies incorporating MALDI-TOF-TOF MS/MS and nanoLC-ES-MS/MS for defining the glycomes of cells, tissues and purified glycoconjugates as well as establishing glycoprotein site-specific glycosylation. The broad range of our research activities will be illustrated by data from ongoing collaborative projects.
Speaker
Stuart Haslam
Organisation: Imperial College London
Travel and Contact Information
Find event
Lecture Theatre
Michael Smith Building
Manchester
