Prof Ruth Baker -- What can identifiable models tell us about regulation of the cell cycle? [IN PERSON]
| Dates: | 17 February 2025 |
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| Times: | 14:00 - 15:00 |
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| What is it: | Seminar |
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| Organiser: | Department of Mathematics |
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| Who is it for: | University staff, External researchers, Current University students |
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| Speaker: | Ruth Baker |
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Join us for this seminar by Prof Ruth Baker (Oxford) as part of the North West Seminar Series in Mathematical Biology and Data Sciences. More details about the joint series can be found here https://northwestseminars.great-site.net/ .
The talk will be hosted in person in room 2.61 of the Simon Building. For those who cannot attend in person the talk will also be streamed via zoom, please contact carl.whitfield@manchester.ac.uk or igor.chernyavsky@manchester.ac.uk for the zoom link, or sign up to the mailing list.
Title: What can identifiable models tell us about regulation of the cell cycle?
Abstract: The spatiotemporal coordination and regulation of cell proliferation is fundamental in many aspects of development and tissue maintenance. Cells can adapt their division rates in response to mechanical checkpoints, yet we do not fully understand how cell proliferation regulation impacts collective cell migration phenomena. I will present a suite of continuum models of collective cell migration with cell cycle dynamics, which differ in their ability to describe crowding constraints and hence cell proliferation regulation. By combining these mathematical models, Bayesian inference, and recent experimental data, I evaluate the level of model complexity that is consistent with the data and quantify the impact of mechanical constraints across different cell cycle stages in epithelial tissue expansion experiments. The modelling results predict that cells sense local density and adapt cell cycle progression in response, both during G1 and the combined S/G2/M phases, and provide an explicit relationship between each cell cycle stage duration and local tissue density.
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Speaker
Ruth Baker
Role: Professor of Applied Mathematics
Organisation: University of Oxford
Travel and Contact Information
Find event
2.61
Simon Building
Manchester
