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PRODID:-//Columba Systems Ltd//NONSGML CPNG/SpringViewer/ICal Output/3.3-
 M3//EN
VERSION:2.0
CALSCALE:GREGORIAN
METHOD:PUBLISH
BEGIN:VEVENT
DTSTAMP:20231010T093820Z
DTSTART:20231018T130000Z
DTEND:20231018T140000Z
SUMMARY:Manchester Neuroscience Seminar Series
UID:{http://www.columbasystems.com/customers/uom/gpp/eventid/}p1xb-lmt5ta
 qh-ik0vbl
DESCRIPTION:"MicroRNA-based therapies for epilepsy"\nMicroRNAs are short 
 noncoding RNA sequences which suppressgene expression by binding to the 
 3’ untranslated region of targetmRNA transcripts. MicroRNAs are dysregul
 ated in epilepsy\, andhave emerged as both biomarkers and therapeutic ta
 rgets for thedisease. The precise molecular and consequent biophysicalme
 chanisms of microRNA manipulation depend on the particulartarget pool of
  each microRNA\, and this has implications for brainexcitability and the
  pathophysiology of epilepsy. I will give anoverview of the field to dat
 e\, and focus on two key publicationswhich have led to the discovery of 
 new microRNA targets forepilepsy\, including microRNA-335\, which can mo
 dulate seizuresvia interaction with Scn2a transcripts
STATUS:TENTATIVE
TRANSP:TRANSPARENT
CLASS:PUBLIC
LOCATION:Michael Smith Building\, Manchester
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