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 M3//EN
VERSION:2.0
CALSCALE:GREGORIAN
METHOD:PUBLISH
BEGIN:VEVENT
DTSTAMP:20130508T141314Z
DTSTART:20130522T120000Z
DTEND:20130522T130000Z
SUMMARY:Mediator Lipidomics: dissecting the role of lipids in inflammatio
 n
UID:{http://www.columbasystems.com/customers/uom/gpp/eventid/}p2y-hggl79u
 f-h56t8h
DESCRIPTION:'''Host:''' School of Pharmacy and Pharmaceutical Sciences\n\
 n'''Speaker:''' Professor Anna Nicolaou\, Professor of Biological Chemis
 try in the Bradford School of Pharmacy\n\n'''About the event:''' \n\nThe
  development of lipidomics has opened new opportunities for lipid biolog
 y allowing the full characterisation of lipid molecular species produced
  by multiple pathways and substrates\, and present in a variety of biolo
 gical milieus. This approach relies on mass spectrometry-based assays an
 d offers a sensitive and versatile platform to study lipids without the 
 constraints of performing lengthy multiple analytical steps or relying o
 n single-metabolite assays\, traditionally associated with lipid analysi
 s. \n\nThe targeted approach of mediator lipidomics deals with the quali
 tative and quantitative analysis of bioactive metabolites of fatty acids
  and phospholipid derivatives that participate in intracellular signalli
 ng and communication. Class members include mediators derived from long 
 chain polyunsaturated fatty acids (PUFA) and generated by cyclooxygenase
  (COX)\, lipoxygenase (LOX) and cytochrome P450 enzymes (such as eicosan
 oids\, docosanoids\, octadecanoids\, HODEs\, HETEs\, HEPEs\, ETEs\, lipo
 xins\, resolvins\, docosatrienes\, and neuroprotectins). These lipids ar
 e intimately involved in inflammation and immunity.\n\nWe have used medi
 ator lipidomics to explore the role of PUFA-derived lipids in skin infla
 mmation\, using the sunburn response as a model system. This revealed th
 e temporal contribution of different lipids starting with an early rise 
 of COX-produced prostaglandins followed by a class switch to LOX-produce
 d hydroxy-eicosatetraenoic acids that may regulate subsequent events lea
 ding to inflammation resolution. The differential contribution of eicosa
 noids in skin of individuals prone and resistant to UVR is also of inter
 est\, whilst nutritional supplementation with n-3PUFA revealed the incre
 ased formation of anti-inflammatory protective species suggesting a poss
 ible role in wound healing and photoprotection.   \n\nOverall\, the resu
 lts of these studies exemplify the prowess and potential of mediator lip
 idomics as a tool for discovery of lipid biomarkers of specific diseases
  as well as in the assessment of nutritional and pharmacological interve
 ntions. \n\n'''A Nicolaou - Biography:'''\n\nAnna Nicolaou is Professor 
 of Biological Chemistry in the Bradford School of Pharmacy. She received
  her BSc in Chemistry and PhD in Biological Chemistry from the Universit
 y of Athens\, and trained as postdoctoral fellow at the School of Pharma
 cy\, University of London. Anna has been working on the molecular mechan
 ism of action of Bioactive Lipids such as polyunsaturated fatty acids\, 
 eicosanoids\, endocannabinoids and phospholipids using mass spectrometry
 -based Lipidomics and aiming to explore the role of lipid networks in he
 alth and disease\; her work has been supported by research councils\, ch
 arities and industry. She is currently co-chair of the Lipidomics divisi
 on of Euro Fed Lipid and associate editor for PLEFA and EJLST.\n\n
STATUS:TENTATIVE
TRANSP:TRANSPARENT
CLASS:PUBLIC
LOCATION:Theatre A\, Coupland Building 3\, Manchester
END:VEVENT
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